Transcriptional effects of copy number alterations in a large set of human cancers

Arkajyoti Bhattacharya; Rico D. Bense; Carlos G. Urzúa-Traslaviña; Elisabeth G. E. de Vries; Marcel A. T. M. van Vugt; Rudolf S. N. Fehrmann

doi:10.1038/s41467-020-14605-5

Nature Communications (Feb 2020)

Transcriptional effects of copy number alterations in a large set of human cancers

Arkajyoti Bhattacharya,
Rico D. Bense,
Carlos G. Urzúa-Traslaviña,
Elisabeth G. E. de Vries,
Marcel A. T. M. van Vugt,
Rudolf S. N. Fehrmann

Affiliations

Arkajyoti Bhattacharya: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Rico D. Bense: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Carlos G. Urzúa-Traslaviña: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Elisabeth G. E. de Vries: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Marcel A. T. M. van Vugt: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Rudolf S. N. Fehrmann: Department of Medical Oncology, University Medical Center Groningen, University of Groningen

DOI: https://doi.org/10.1038/s41467-020-14605-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expression data without requiring paired CNA profiles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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