Correlation of Peripheral Blood CD14+CD16+ Monocytes, Urinary Neopterin and the Risk Factors of Atherosclerosis in Patients with Breast Carcinoma
Králíčková Pavlína,
Kalábová Hana,
Krčmová Lenka,
Kašparová Markéta,
Plíšek Jiří,
Ungermann Leoš,
Vokurková Doris,
Hyšpler Radomír,
Pecka Miroslav,
Šrámek Vlastislav,
Študentová Hana,
Zezulová Michaela,
Solichová Dagmar,
Melichar Bohuslav
Affiliations
Králíčková Pavlína
Departments of Immunology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Kalábová Hana
Departments of Oncology & Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Krčmová Lenka
Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Kašparová Markéta
Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Plíšek Jiří
Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Ungermann Leoš
Departments of Radiology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Vokurková Doris
Departments of Immunology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Hyšpler Radomír
Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Pecka Miroslav
Departments of Hematology, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Šrámek Vlastislav
Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
Študentová Hana
Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
Zezulová Michaela
Department of Oncology, Palacký University Medical School Teaching Hospital, Olomouc, Czech Republic
Solichová Dagmar
Departments of Gerontology & Metabolic Care, Charles University Medical School Teaching Hospital, Hradec Králové, Czech Republic
Melichar Bohuslav
Professor and Head, Department of Oncology, Palacký University Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic phone: +420-588444288; fax: +420-588442522
Monocytes/macrophages are thought to play a fundamental role in the development of vascular lesions in atherosclerosis. In the present study, we evaluated circulating CD14+CD16+ monocytes, laboratory parameters of the risk of atherosclerosis, including serum cholesterol, homocysteine and C-reactive protein, urinary neopterin, serum a-tocopherol and retinol along with carotid intima-media thickness in patients with breast carcinoma. A significant correlation was observed between the absolute numbers of CD14+CD16+ monocytes, serum HDL cholesterol and triglyceride concentrations. In conclusion, present data extend the observation of an association between peripheral blood CD14+CD16+ monocyte counts and lipid metabolism to cancer patients. No correlation of CD14+CD16+ monocyte counts with urinary neopterin concentrations was observed.
