Local Treatment Combined with EGFR-TKIs for Advanced Non-small Cell Lung Cancer with Solitary Progression during EGFR-TKI Treatment

Abstract

Background and objective Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are routine treatments for non-small cell lung cancer (NSCLC) with EGFR mutation. Different clinical modes can be used to treat patients with TKI resistance, one of which is solitary progression. The aim of this study is to analyze available treatments for patients undergoing solitary progression. Methods Clinical data of 45 patients with advanced NSCLC who received local radiotherapy combined with EGFR-TKI after solitary progression were reviewed and analyzed. Results Among the 45 patients, 11 showed partial response, 23 achieved stable disease state, and 11 experienced progressive disease. The median of progression-free survival (PFS) was 5.9 months. Conclusion Local therapies combined with EGFR-TKIs can prolong the PFS of patients with NSCLC who exhibited solitary progression during EGFR-TKI treatment.

Keywords

• Lung neoplsms
• Epidermal growth factor receptor tyrosine kinase inhibitors
• Solitary progression