Nature Communications (Sep 2021)

Microglia have a grip on brain microvasculature

  • Kassandra Kisler,
  • Angeliki Maria Nikolakopoulou,
  • Berislav V. Zlokovic

DOI
https://doi.org/10.1038/s41467-021-25595-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 3

Abstract

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Microglia are brain resident immune cells with multiple functions. However, little is known about microglia-vascular interactions. In a recent paper published in Nature Communications, Bisht et al. identify a signalling mechanism that attracts and maintains microglia at the capillary wall. Moreover, they show that microglia regulate capillary vascular tone, playing a more significant role in blood flow regulation than previously thought.