Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture

• Saikat Manna,
• William J. Howitz,
• Nathan J. Oldenhuis,
• Alexander C. Eldredge,
• Jingjing Shen,
• Fnu Naorem Nihesh,
• Melissa B. Lodoen,
• Zhibin Guan,
• Aaron P. Esser-Kahn

Affiliations

Saikat Manna

Department of Chemistry, University of California, Irvine, Irvine, California, United States

William J. Howitz

Department of Chemistry, University of California, Irvine, Irvine, California, United States

Nathan J. Oldenhuis

Department of Chemistry, University of California, Irvine, Irvine, California, United States

Alexander C. Eldredge

Department of Chemistry, University of California, Irvine, Irvine, California, United States

Jingjing Shen

Institute for Molecular Engineering, University of Chicago, Chicago, Illinois, United States

Fnu Naorem Nihesh

Department of Chemistry, University of California, Irvine, Irvine, California, United States

Melissa B. Lodoen

The Institute for Immunology, University of California, Irvine, Irvine, California, United States

Zhibin Guan

Department of Chemistry, University of California, Irvine, Irvine, California, United States

Aaron P. Esser-Kahn

Department of Chemistry, University of California, Irvine, Irvine, California, United States