The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Max Meyrath; Martyna Szpakowska; Julian Zeiner; Laurent Massotte; Myriam P. Merz; Tobias Benkel; Katharina Simon; Jochen Ohnmacht; Jonathan D. Turner; Rejko Krüger; Vincent Seutin; Markus Ollert; Evi Kostenis; Andy Chevigné

doi:10.1038/s41467-020-16664-0

Nature Communications (Jun 2020)

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Max Meyrath,
Martyna Szpakowska,
Julian Zeiner,
Laurent Massotte,
Myriam P. Merz,
Tobias Benkel,
Katharina Simon,
Jochen Ohnmacht,
Jonathan D. Turner,
Rejko Krüger,
Vincent Seutin,
Markus Ollert,
Evi Kostenis,
Andy Chevigné

Affiliations

Max Meyrath: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29
Martyna Szpakowska: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29
Julian Zeiner: Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6
Laurent Massotte: Neurophysiology Unit, GIGA Neurosciences, University of Liège, avenue de l’hopital
Myriam P. Merz: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29
Tobias Benkel: Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6
Katharina Simon: Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6
Jochen Ohnmacht: Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, avenue du Swing 6
Jonathan D. Turner: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29
Rejko Krüger: Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, avenue du Swing 6
Vincent Seutin: Neurophysiology Unit, GIGA Neurosciences, University of Liège, avenue de l’hopital
Markus Ollert: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29
Evi Kostenis: Molecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Nussallee 6
Andy Chevigné: Department of Infection and Immunity, Luxembourg Institute of Health (LIH), rue Henri Koch 29

DOI: https://doi.org/10.1038/s41467-020-16664-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Opioids modulate pain, anxiety and stress by activating four subtypes of opioid receptors. The authors show that atypical chemokine receptor 3 (ACKR3) is a scavenger for various endogenous opioid peptides regulating their availability without activating downstream signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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