Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation Trial in the Ambulance (Mobile Stroke Unit—TASTE-A): protocol for a prospective randomised, open-label, blinded endpoint, phase II superiority trial of tenecteplase versus alteplase for ischaemic stroke patients presenting within 4.5 hours of symptom onset to the mobile stroke unit

• Geoffrey A Donnan,
• Stephen M Davis,
• Karen Smith,
• Vincent Thijs,
• Philip Choi,
• Michael Valente,
• Leonid Churilov,
• Bruce Campbell,
• Tissa Wijeratne,
• Henry Ma,
• Andrew Bivard,
• Michael Stephenson,
• Henry Zhao,
• Geoffrey Cloud,
• Bernard Yan,
• Mark Parsons,
• Angelos Sharobeam,
• Skye Coote,
• Francesca Langenberg,
• Nawaf Yassi,
• Anna Balabanski,
• Angela Dos Santos,
• Felix Ng,
• Steve Bernard,
• Chushuang Chen,
• Liudmyla Olenko

Affiliations

Geoffrey A Donnan

director

Stephen M Davis

Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia

Karen Smith

2 Research and Evaluation, Ambulance Victoria, Melbourne, Victoria, Australia

Vincent Thijs

Department of Neurology, Austin Health, Heidelberg, Victoria, Australia

Philip Choi

Department of Neurology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia

Michael Valente

Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA

Leonid Churilov

head of statistics and informatics platform

Bruce Campbell

Department of Medicine and Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, Melbourne, Austria

Tissa Wijeratne

Western Health Chronic Disease Alliance, Melbourne, Victoria, Australia

Henry Ma

Department of Neurology, Monash Medical Centre, Monash University, Clayton, Victoria, Australia

Andrew Bivard

Department of Medicine and Neurology, Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia

Michael Stephenson

Ambulance Victoria, Doncaster, Victoria, Australia

Henry Zhao

Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Geoffrey Cloud

Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia

Bernard Yan

Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Mark Parsons

School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, New South Wales, Australia

Angelos Sharobeam

Melbourne Brain Centre at Royal Melbourne Hospital, Parkville, Victoria, Australia

Skye Coote

1The Melbourne Brain Centre and Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia

Francesca Langenberg

3Department of Radiology, Royal Melbourne Hospital, Melbourne, VIC, Australia

Nawaf Yassi

Department of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia

Anna Balabanski

Research and Evaluation, Ambulance Victoria, Doncaster, Victoria, Australia

Angela Dos Santos

Research and Evaluation, Ambulance Victoria, Doncaster, Victoria, Australia

Felix Ng

Department of Medicine and Neurology, The University of Melbourne, Melbourne, Victoria, Australia

Steve Bernard

Ambulance Victoria, Doncaster, Victoria, Australia

Chushuang Chen

Department of Medicine and Neurology, The University of Melbourne, Melbourne, Victoria, Australia

Liudmyla Olenko

Department of Medicine and Neurology, The University of Melbourne, Melbourne, Victoria, Australia