Green Processing and Synthesis (Jun 2018)

Eco-friendly synthesis, characterization, and drug-likeness properties of new uracils and their biological evaluation

  • Fadda Ahmed A.,
  • Fekri Ahmed,
  • Bayoumy Nesma M.

DOI
https://doi.org/10.1515/gps-2016-0199
Journal volume & issue
Vol. 7, no. 3
pp. 198 – 206

Abstract

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Several pyridopyrimidine derivatives have been synthesized through different synthetic processes. The different physicochemical factors for their synthesis were also discussed. A comparison between the conventional and microwave-assisted synthesis was conducted by comparing total time of reaction and its yield percentage. Most of the produced uracils were established for their anti-inflammatory, analgesic, and antioxidant activities. Compounds 1 and 3 were demonstrated as the best results against DNA damage, whereas compounds 2a and 2b exhibited an effective anti-inflammatory activity. Moreover, the Lipinski rule parameters were calculated for the synthesized compounds. The results indicated that compounds 1, 2a and 5 have good potential for subsequent development bioactivity.

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