Analysis of Acute Phase Response Using Acute Phase Proteins Following Simultaneous Vaccination of Lumpy Skin Disease and Foot-and-Mouth Disease
Jiyeon Kim,
Danil Kim,
Hyoeun Noh,
Leegon Hong,
Eunwoo Chun,
Eunkyung Kim,
Younghye Ro,
Woojae Choi
Affiliations
Jiyeon Kim
Department of Farm Animal Medicine, College of Veterinary, Seoul National University, Seoul 08826, Republic of Korea
Danil Kim
Department of Farm Animal Medicine, College of Veterinary, Seoul National University, Seoul 08826, Republic of Korea
Hyoeun Noh
Department of Farm Animal Medicine, College of Veterinary, Seoul National University, Seoul 08826, Republic of Korea
Leegon Hong
Department of Farm Animal Medicine, College of Veterinary, Seoul National University, Seoul 08826, Republic of Korea
Eunwoo Chun
Farm Animal Clinical Training and Research Center, Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea
Eunkyung Kim
Farm Animal Clinical Training and Research Center, Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea
Younghye Ro
Department of Large Animal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea
Woojae Choi
Farm Animal Clinical Training and Research Center, Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea
Since 2011, South Korea has implemented biannual vaccinations against foot-and-mouth disease (FMD) and recently, lumpy skin disease (LSD), to mitigate the spread of transboundary animal diseases. However, due to past adverse reactions, potentially linked to acute phase responses from FMD vaccinations, there is hesitancy among Korean livestock farmers regarding new strategies for simultaneous vaccinations against both FMD and LSD. This study was conducted to assess possible adverse reactions to the LSD vaccination by analyzing acute phase proteins (APPs) in three groups: cows vaccinated against FMD (G1-FMDV), LSD (G2-LSDV), and both (G3-FMDV/LSDV). In G1-FMDV, APP levels peaked on day 3 post-vaccination (p p < 0.001). These results indicate that LSD vaccines trigger a later immune response compared to FMD vaccines, possibly due to different adjuvants. Therefore, a longer follow-up period for monitoring adverse reactions to LSD vaccinations may be required to understand and mitigate potential risks.
