Frontiers in Immunology (Nov 2020)
Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy
- Ann-Marie Malby Schoos,
- Ann-Marie Malby Schoos,
- Dominique Bullens,
- Dominique Bullens,
- Bo Lund Chawes,
- Joana Costa,
- Liselot De Vlieger,
- Audrey DunnGalvin,
- Audrey DunnGalvin,
- Michelle M. Epstein,
- Johan Garssen,
- Johan Garssen,
- Christiane Hilger,
- Karen Knipping,
- Karen Knipping,
- Annette Kuehn,
- Dragan Mijakoski,
- Dragan Mijakoski,
- Daniel Munblit,
- Daniel Munblit,
- Nikita A. Nekliudov,
- Cevdet Ozdemir,
- Cevdet Ozdemir,
- Karine Patient,
- Diego Peroni,
- Sasho Stoleski,
- Sasho Stoleski,
- Eva Stylianou,
- Mirjana Tukalj,
- Mirjana Tukalj,
- Mirjana Tukalj,
- Kitty Verhoeckx,
- Mihaela Zidarn,
- Willem van de Veen,
- Willem van de Veen
Affiliations
- Ann-Marie Malby Schoos
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
- Ann-Marie Malby Schoos
- Department of Pediatrics, Slagelse Sygehus, Slagelse, Denmark
- Dominique Bullens
- Allergy and Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
- Dominique Bullens
- Clinical Division of Pediatrics, UZ Leuven, Leuven, Belgium
- Bo Lund Chawes
- COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
- Joana Costa
- REQUIMTE-LAQV, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
- Liselot De Vlieger
- Allergy and Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
- Audrey DunnGalvin
- School of Applied Psychology, University College Cork, Cork, Ireland
- Audrey DunnGalvin
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
- Michelle M. Epstein
- Experimental Allergy Laboratory, Department of Dermatology, Medical University of Vienna, Vienna, Austria
- Johan Garssen
- Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
- Johan Garssen
- 0Centre of Excellence Immunology, Danone Nutricia research, Utrecht, Netherlands
- Christiane Hilger
- 1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg
- Karen Knipping
- Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands
- Karen Knipping
- 0Centre of Excellence Immunology, Danone Nutricia research, Utrecht, Netherlands
- Annette Kuehn
- 1Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg
- Dragan Mijakoski
- 2Institute of Occupational Health of RNM, Skopje, North Macedonia
- Dragan Mijakoski
- 3Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
- Daniel Munblit
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
- Daniel Munblit
- 4Inflammation, Repair and Development Section, NHLI, Imperial College London, London, United Kingdom
- Nikita A. Nekliudov
- Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
- Cevdet Ozdemir
- 5Institute of Child Health, Department of Pediatric Basic Sciences, Istanbul University, Istanbul, Turkey
- Cevdet Ozdemir
- 6Division of Pediatric Allergy and Immunology, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
- Karine Patient
- 7SPI—Food Allergy Unit, Département Médicaments et Technologies pour la Santé (DMTS), Université Paris Saclay, CEA, INRAE, Gif-sur-Yvette, France
- Diego Peroni
- 8Section of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
- Sasho Stoleski
- 2Institute of Occupational Health of RNM, Skopje, North Macedonia
- Sasho Stoleski
- 3Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
- Eva Stylianou
- 9Regional Unit for Asthma, Allergy and Hypersensitivity, Department of Pulmonary Diseases, Oslo University Hospital, Oslo, Norway
- Mirjana Tukalj
- 0Children’s Hospital, Department of Allergology and Pulmonology, Zagreb, Croatia
- Mirjana Tukalj
- 1Faculty of Medicine, University of Osijek, Osijek, Croatia
- Mirjana Tukalj
- 2Catholic University of Croatia, Zagreb, Croatia
- Kitty Verhoeckx
- 3Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht, Netherlands
- Mihaela Zidarn
- 4University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
- Willem van de Veen
- 5Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland
- Willem van de Veen
- 6Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
- DOI
- https://doi.org/10.3389/fimmu.2020.568598
- Journal volume & issue
-
Vol. 11
Abstract
IgE-mediated food allergies are caused by adverse immunologic responses to food proteins. Allergic reactions may present locally in different tissues such as skin, gastrointestinal and respiratory tract and may result is systemic life-threatening reactions. During the last decades, the prevalence of food allergies has significantly increased throughout the world, and considerable efforts have been made to develop curative therapies. Food allergen immunotherapy is a promising therapeutic approach for food allergies that is based on the administration of increasing doses of culprit food extracts, or purified, and sometime modified food allergens. Different routes of administration for food allergen immunotherapy including oral, sublingual, epicutaneous and subcutaneous regimens are being evaluated. Although a wealth of data from clinical food allergen immunotherapy trials has been obtained, a lack of consistency in assessed clinical and immunological outcome measures presents a major hurdle for evaluating these new treatments. Coordinated efforts are needed to establish standardized outcome measures to be applied in food allergy immunotherapy studies, allowing for better harmonization of data and setting the standards for the future research. Several immunological parameters have been measured in food allergen immunotherapy, including allergen-specific immunoglobulin levels, basophil activation, cytokines, and other soluble biomarkers, T cell and B cell responses and skin prick tests. In this review we discuss different immunological parameters and assess their applicability as potential outcome measures for food allergen immunotherapy that may be included in such a standardized set of outcome measures.
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