Nature Communications (Jun 2020)
Mode of action of teixobactins in cellular membranes
- Rhythm Shukla,
- João Medeiros-Silva,
- Anish Parmar,
- Bram J. A. Vermeulen,
- Sanjit Das,
- Alessandra Lucini Paioni,
- Shehrazade Jekhmane,
- Joseph Lorent,
- Alexandre M. J. J. Bonvin,
- Marc Baldus,
- Moreno Lelli,
- Edwin J. A. Veldhuizen,
- Eefjan Breukink,
- Ishwar Singh,
- Markus Weingarth
Affiliations
- Rhythm Shukla
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- João Medeiros-Silva
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Anish Parmar
- School of Pharmacy, JBL Building, University of Lincoln
- Bram J. A. Vermeulen
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Sanjit Das
- School of Pharmacy, JBL Building, University of Lincoln
- Alessandra Lucini Paioni
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Shehrazade Jekhmane
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Joseph Lorent
- Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht University
- Alexandre M. J. J. Bonvin
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Marc Baldus
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- Moreno Lelli
- Department of Chemistry ‘Ugo Schiff’, University of Florence
- Edwin J. A. Veldhuizen
- Section Molecular Host Defence, Division Infectious Diseases & Immunology, Department Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University
- Eefjan Breukink
- Membrane Biochemistry and Biophysics, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Utrecht University
- Ishwar Singh
- School of Pharmacy, JBL Building, University of Lincoln
- Markus Weingarth
- NMR Spectroscopy, Bijvoet Centre for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University
- DOI
- https://doi.org/10.1038/s41467-020-16600-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
The natural antibiotic teixobactin kills bacteria by direct binding to their cognate cell wall precursors (Lipid II and III). Here authors use solid-state NMR to reveal the native binding mode of teixobactins and show that teixobactins only weakly bind to Lipid II in anionic cellular membranes.
