Nature Communications (Jul 2021)
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
- Wenyu Wang,
- Yen-An Tang,
- Qian Xiao,
- Wee Chyan Lee,
- Bing Cheng,
- Zhitong Niu,
- Gokce Oguz,
- Min Feng,
- Puay Leng Lee,
- Baojie Li,
- Zi-huan Yang,
- Yu-feng Chen,
- Ping Lan,
- Xiao-Jian Wu,
- Qiang Yu
Affiliations
- Wenyu Wang
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Yen-An Tang
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- Qian Xiao
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Wee Chyan Lee
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- Bing Cheng
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Zhitong Niu
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Gokce Oguz
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- Min Feng
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- Puay Leng Lee
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- Baojie Li
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Zi-huan Yang
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Yu-feng Chen
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Ping Lan
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Xiao-Jian Wu
- Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Qiang Yu
- Cancer Precision Medicine, Genome Institute of Singapore, Agency for Science, Technology, and Research
- DOI
- https://doi.org/10.1038/s41467-021-24687-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signaling.
