Evaluation of Immunogenicity and Safety of Vero Cell-Derived Inactivated COVID-19 Vaccine in Older Patients with Hypertension and Diabetes Mellitus
Yuntao Zhang,
Haiping Chen,
Jun Lv,
Tao Huang,
Ruizhi Zhang,
Dongjuan Zhang,
Linyun Luo,
Sheng Wei,
Xiaoqin Liu,
Shangxiao Zhang,
Qiuyue Mu,
Rongdong Huang,
Jiao Huang,
Yanhui Xiao,
Yunkai Yang,
Yuting Han,
Hao Gong,
Qinghu Guan,
Fangqin Xie,
Hui Wang,
Liming Li,
Xiaoming Yang
Affiliations
Yuntao Zhang
China National Biotech Group Co., Ltd., Beijing 100024, China
Haiping Chen
China National Biotech Group Co., Ltd., Beijing 100024, China
Jun Lv
Peking University Center for Public Health and Epidemic Preparedness & Response, Department of Epidemiology & Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China
Tao Huang
Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China
Ruizhi Zhang
Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China
Dongjuan Zhang
Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350012, China
Linyun Luo
China National Biotech Group Co., Ltd., Beijing 100024, China
Sheng Wei
School of Public Health, Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430074, China
Xiaoqin Liu
China National Biotech Group Co., Ltd., Beijing 100024, China
Shangxiao Zhang
Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China
Qiuyue Mu
Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China
Rongdong Huang
Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350012, China
Jiao Huang
Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
Yanhui Xiao
China National Biotech Group Co., Ltd., Beijing 100024, China
Yunkai Yang
China National Biotech Group Co., Ltd., Beijing 100024, China
Yuting Han
Peking University Center for Public Health and Epidemic Preparedness & Response, Department of Epidemiology & Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China
Hao Gong
Linli County Center for Disease Control and Prevention, Changde 415200, China
Qinghu Guan
Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China
Fangqin Xie
Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350012, China
Hui Wang
Beijing Institute of Biological Products Co., Ltd., Beijing 100176, China
Liming Li
Peking University Center for Public Health and Epidemic Preparedness & Response, Department of Epidemiology & Biostatistics, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China
Xiaoming Yang
China National Biotech Group Co., Ltd., Beijing 100024, China
Background: To evaluate the immunogenicity and safety of the COVID-19 vaccine (Vero cell), inactivated, in a population aged ≥60 years with hypertension or(/and) diabetes mellitus. Methods: A total of 1440 participants were enrolled and divided into four groups, 330 in the hypertension group, 330 in the diabetes group, 300 in the hypertensive combined with diabetes group (combined disease group), and 480 in the healthy population group. Two doses of the COVID-19 vaccine (Vero cell), inactivated, were administered at a 21-day interval and blood samples were collected before vaccination and 28 days after the second dose to evaluate the immunogenicity. The adverse events and changes in blood pressure and blood glucose levels after vaccination were recorded. Results: The seroconversion rate of the COVID-19 neutralizing antibodies was 100% for all participants. The post-inoculation geometric mean titer (GMT) in the four groups of the hypertension, diabetes, combined disease, and healthy populations were 73.41, 69.93, 73.84, and 74.86, respectively. The seroconversion rates and post-vaccination GMT in the hypertension, diabetes, and combined disease groups were non-inferior to the healthy population group. The rates of vaccine-related adverse reactions were 11.93%, 14.29%, 12.50%, and 9.38%, respectively. No serious adverse events were reported during the study. No apparent abnormal fluctuations in blood pressure and blood glucose values were observed after vaccination in participants with hypertension or(/and) diabetes. Conclusions: The COVID-19 vaccine (Vero cell), inactivated, showed good immunogenicity and safety in patients aged ≥60 years suffering from hypertension or(/and) diabetes mellitus.
