Nature Communications (Dec 2019)
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID
- Guillermo Rodríguez-Hernández,
- Friederike V. Opitz,
- Pilar Delgado,
- Carolin Walter,
- Ángel F. Álvarez-Prado,
- Inés González-Herrero,
- Franziska Auer,
- Ute Fischer,
- Stefan Janssen,
- Christoph Bartenhagen,
- Javier Raboso-Gallego,
- Ana Casado-García,
- Alberto Orfao,
- Oscar Blanco,
- Diego Alonso-López,
- Javier De Las Rivas,
- Sara González de Tena-Dávila,
- Markus Müschen,
- Martin Dugas,
- Francisco Javier García Criado,
- María Begoña García Cenador,
- Carolina Vicente-Dueñas,
- Julia Hauer,
- Almudena R. Ramiro,
- Isidro Sanchez-Garcia,
- Arndt Borkhardt
Affiliations
- Guillermo Rodríguez-Hernández
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Friederike V. Opitz
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- Pilar Delgado
- B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares
- Carolin Walter
- Institute of Medical Informatics, University of Muenster
- Ángel F. Álvarez-Prado
- B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares
- Inés González-Herrero
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Franziska Auer
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- Ute Fischer
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- Stefan Janssen
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- Christoph Bartenhagen
- Department of Experimental Pediatric Oncology, University Children’s Hospital of Cologne, Medical Faculty
- Javier Raboso-Gallego
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Ana Casado-García
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Alberto Orfao
- Institute of Biomedical Research of Salamanca (IBSAL)
- Oscar Blanco
- Institute of Biomedical Research of Salamanca (IBSAL)
- Diego Alonso-López
- Bioinformatics Unit, Cancer Research Center (CSIC-USAL)
- Javier De Las Rivas
- Institute of Biomedical Research of Salamanca (IBSAL)
- Sara González de Tena-Dávila
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Markus Müschen
- Department of Systems Biology, City of Hope Comprehensive Cancer Center
- Martin Dugas
- Institute of Medical Informatics, University of Muenster
- Francisco Javier García Criado
- Institute of Biomedical Research of Salamanca (IBSAL)
- María Begoña García Cenador
- Institute of Biomedical Research of Salamanca (IBSAL)
- Carolina Vicente-Dueñas
- Institute of Biomedical Research of Salamanca (IBSAL)
- Julia Hauer
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- Almudena R. Ramiro
- B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares
- Isidro Sanchez-Garcia
- Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca
- Arndt Borkhardt
- Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
- DOI
- https://doi.org/10.1038/s41467-019-13570-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.
