STRUCTURE AND ADJUVANTICITY IMMUNE PROPERTIES OF MURAMYLDIPEPTIDE

Abstract

Muramyl dipeptide (MDP) is a minimal peptidoglycan motif common to Gram-negative and Gram-positive bacteria, activate both innate and. adaptive immunity. MDP are recognized by Nod2-like-receptor that triggers of cell signaling pathways induction, activates of proinflammatory cytokine synthesis. In present review we consider structure, functions, adjuvanticity, immune properties and. clinical usage perspectives of MDP and. other muropeptides.

Keywords

• nod2-подобные рецепторы (nlr2)
• muramyldipeptide (mdp)
• nod2-like-receptor (nlr2)
• immunomodulator
• adjuvant