Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

Joshua M. Boucher; Ryan P. Clark; Diana C. Chong; Kathryn M. Citrin; Lyndsay A. Wylie; Victoria L. Bautch

doi:10.1038/ncomms15699

Nature Communications (Jun 2017)

Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis

Joshua M. Boucher,
Ryan P. Clark,
Diana C. Chong,
Kathryn M. Citrin,
Lyndsay A. Wylie,
Victoria L. Bautch

Affiliations

Joshua M. Boucher: Department of Biology, University of North Carolina at Chapel Hill
Ryan P. Clark: Department of Biology, University of North Carolina at Chapel Hill
Diana C. Chong: Genetics and Molecular Biology Curriculum, University of North Carolina at Chapel Hill
Kathryn M. Citrin: Department of Biology, University of North Carolina at Chapel Hill
Lyndsay A. Wylie: Genetics and Molecular Biology Curriculum, University of North Carolina at Chapel Hill
Victoria L. Bautch: Department of Biology, University of North Carolina at Chapel Hill

DOI: https://doi.org/10.1038/ncomms15699
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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