Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis

Minge Du; Zuanning Yuan; Glenn T. Werneburg; Nadine S. Henderson; Hemil Chauhan; Amanda Kovach; Gongpu Zhao; Jessica Johl; Huilin Li; David G. Thanassi

doi:10.1038/s41467-021-25522-6

Nature Communications (Sep 2021)

Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis

Minge Du,
Zuanning Yuan,
Glenn T. Werneburg,
Nadine S. Henderson,
Hemil Chauhan,
Amanda Kovach,
Gongpu Zhao,
Jessica Johl,
Huilin Li,
David G. Thanassi

Affiliations

Minge Du: Department of Structural Biology, Van Andel Institute
Zuanning Yuan: Department of Structural Biology, Van Andel Institute
Glenn T. Werneburg: Department of Microbiology and Immunology, Stony Brook University, Stony Brook
Nadine S. Henderson: Department of Microbiology and Immunology, Stony Brook University, Stony Brook
Hemil Chauhan: Department of Microbiology and Immunology, Stony Brook University, Stony Brook
Amanda Kovach: Department of Structural Biology, Van Andel Institute
Gongpu Zhao: Department of Structural Biology, Van Andel Institute
Jessica Johl: Department of Microbiology and Immunology, Stony Brook University, Stony Brook
Huilin Li: Department of Structural Biology, Van Andel Institute
David G. Thanassi: Department of Microbiology and Immunology, Stony Brook University, Stony Brook

DOI: https://doi.org/10.1038/s41467-021-25522-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Escherichia coli form pili structures in order to initiate infection of the urinary tract. Here, Thanassi et al., have solved the structures of pili assembly intermediates and provided insights into their biogenesis and assembly.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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