Nature Communications (Nov 2022)
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
Abstract
The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. Here the authors report that a SUMO-specific protease, SENP1, deSUMOylates RIPK1 and inhibits cell death in a mouse model of non-alcoholic fatty liver disease.