Nature Communications (Nov 2022)

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

  • Lingjie Yan,
  • Tao Zhang,
  • Kai Wang,
  • Zezhao Chen,
  • Yuanxin Yang,
  • Bing Shan,
  • Qi Sun,
  • Mengmeng Zhang,
  • Yichi Zhang,
  • Yedan Zhong,
  • Nan Liu,
  • Jinyang Gu,
  • Daichao Xu

DOI
https://doi.org/10.1038/s41467-022-34993-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. Here the authors report that a SUMO-specific protease, SENP1, deSUMOylates RIPK1 and inhibits cell death in a mouse model of non-alcoholic fatty liver disease.