Nature Communications (Feb 2022)
A mammalian methylation array for profiling methylation levels at conserved sequences
- Adriana Arneson,
- Amin Haghani,
- Michael J. Thompson,
- Matteo Pellegrini,
- Soo Bin Kwon,
- Ha Vu,
- Emily Maciejewski,
- Mingjia Yao,
- Caesar Z. Li,
- Ake T. Lu,
- Marco Morselli,
- Liudmilla Rubbi,
- Bret Barnes,
- Kasper D. Hansen,
- Wanding Zhou,
- Charles E. Breeze,
- Jason Ernst,
- Steve Horvath
Affiliations
- Adriana Arneson
- Bioinformatics Interdepartmental Program, University of California
- Amin Haghani
- Dept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Michael J. Thompson
- Molecular, Cell and Developmental Biology, University of California Los Angeles
- Matteo Pellegrini
- Molecular, Cell and Developmental Biology, University of California Los Angeles
- Soo Bin Kwon
- Bioinformatics Interdepartmental Program, University of California
- Ha Vu
- Bioinformatics Interdepartmental Program, University of California
- Emily Maciejewski
- Department of Biological Chemistry, University of California, Los Angeles
- Mingjia Yao
- Dept. of Biostatistics, Fielding School of Public Health, University of California Los Angeles
- Caesar Z. Li
- Dept. of Biostatistics, Fielding School of Public Health, University of California Los Angeles
- Ake T. Lu
- Dept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- Marco Morselli
- Molecular, Cell and Developmental Biology, University of California Los Angeles
- Liudmilla Rubbi
- Molecular, Cell and Developmental Biology, University of California Los Angeles
- Bret Barnes
- Illumina, Inc
- Kasper D. Hansen
- Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
- Wanding Zhou
- Center for Computational and Genomic Medicine, Children’s Hospital of Philadelphia
- Charles E. Breeze
- Altius Institute for Biomedical Sciences
- Jason Ernst
- Bioinformatics Interdepartmental Program, University of California
- Steve Horvath
- Dept. of Human Genetics, David Geffen School of Medicine, University of California Los Angeles
- DOI
- https://doi.org/10.1038/s41467-022-28355-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Methods to probe DNA methylation in the majority of non-human mammals are lacking. Here the authors developed a Mammalian Methylation Array that includes 36k well-conserved CpGs in mammals which will facilitate cross-species comparisons. They annotate the conserved CpGs in > 200 species. The array allows one to measure methylation in all mammalian species including unsequenced ones.
