Frontiers in Pharmacology (Feb 2022)
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps
- Chengji Dong,
- Chengji Dong,
- Chengji Dong,
- Zhuliu Chen,
- Zhuliu Chen,
- Zhuliu Chen,
- Linxin Zhu,
- Linxin Zhu,
- Najeeb Bsoul,
- Najeeb Bsoul,
- Hongqiang Wu,
- Hongqiang Wu,
- Hongqiang Wu,
- Jingtao Jiang,
- Jingtao Jiang,
- Jingtao Jiang,
- Xuankuai Chen,
- Xuankuai Chen,
- Xuankuai Chen,
- Yingying Lai,
- Yingying Lai,
- Yingying Lai,
- Gaoxiang Yu,
- Gaoxiang Yu,
- Gaoxiang Yu,
- Yanlan Gu,
- Xiaoshan Guo,
- Xiaoshan Guo,
- Weiyang Gao,
- Weiyang Gao
Affiliations
- Chengji Dong
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Chengji Dong
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Chengji Dong
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Zhuliu Chen
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Zhuliu Chen
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Zhuliu Chen
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Linxin Zhu
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Linxin Zhu
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Najeeb Bsoul
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Najeeb Bsoul
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Hongqiang Wu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Hongqiang Wu
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Hongqiang Wu
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Jingtao Jiang
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Jingtao Jiang
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Jingtao Jiang
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Xuankuai Chen
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Xuankuai Chen
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Xuankuai Chen
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Yingying Lai
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Yingying Lai
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Yingying Lai
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Gaoxiang Yu
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Gaoxiang Yu
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Gaoxiang Yu
- The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China
- Yanlan Gu
- Department of Histology and Embryology, Wenzhou Medical University, Zhejiang, China
- Xiaoshan Guo
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Xiaoshan Guo
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- Weiyang Gao
- Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
- Weiyang Gao
- Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, China
- DOI
- https://doi.org/10.3389/fphar.2022.809034
- Journal volume & issue
-
Vol. 13
Abstract
The multiterritory perforator flap is one of the widest flap patterns used to repair tissue defects. However, flap necrosis of the distal part is still a challenging issue for plastic surgeons. Diallyl trisulfide (DATS) is an efficient ingredient extracted from garlic, exerting many important effects on different diseases. Our experiment aims to reveal whether DATS has a beneficial effect on the survival of perforator flaps and to explore its mechanism of action. The results showed that DATS enhanced angiogenesis and autophagy and reduced cell apoptosis and oxidative stress, thereby improving the survival rate of skin flaps. After co-administration with autophagy inhibitor 3-methyladenine (3MA), perforator flap survival was further improved. Mechanistically, we showed that PI3K/Akt and AMPK-HIF-1α signaling pathways in flap were activated under DATS treatment. All in all, DATS promoted the survival of multiterritory perforator flaps via the synergistic regulation of PI3K/Akt and AMPK-HIF-1α signaling pathways, and inhibition of DATS-induced autophagy further improves flap survival.
Keywords
