Nature Communications (Jan 2016)
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress
- Tim I. M. Malcolm,
- Patrick Villarese,
- Camilla J. Fairbairn,
- Laurence Lamant,
- Amélie Trinquand,
- C. Elizabeth Hook,
- G. A. Amos Burke,
- Laurence Brugières,
- Katherine Hughes,
- Dominique Payet,
- Olaf Merkel,
- Ana-Iris Schiefer,
- Ibraheem Ashankyty,
- Shahid Mian,
- Mariusz Wasik,
- Martin Turner,
- Lukas Kenner,
- Vahid Asnafi,
- Elizabeth Macintyre,
- Suzanne D. Turner
Affiliations
- Tim I. M. Malcolm
- Department of Pathology, University of Cambridge
- Patrick Villarese
- Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France
- Camilla J. Fairbairn
- Department of Pathology, University of Cambridge
- Laurence Lamant
- Institut Universitaire de Cancérologie Oncopole
- Amélie Trinquand
- Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France
- C. Elizabeth Hook
- Department of Histopathology and Cytology, Addenbrooke’s Hospital
- G. A. Amos Burke
- Department of Paediatric Oncology, Addenbrooke’s Hospital
- Laurence Brugières
- Département de Cancérologie de l’Enfant et l’Adolescent, Gustave Roussy
- Katherine Hughes
- Department of Veterinary Medicine, University of Cambridge
- Dominique Payet
- Centre d’Immunologie de Marseille Luminy (CIML), INSERM UMR1104, CNRS UMR7280, Aix-Marseille Université UM2
- Olaf Merkel
- Clinical Institute of Pathology, Medical University of Vienna
- Ana-Iris Schiefer
- Clinical Institute of Pathology, Medical University of Vienna
- Ibraheem Ashankyty
- Molecular Diagnostics and Personalized Therapeutics Unit, College of Applied Medical Sciences University of Ha’il
- Shahid Mian
- Molecular Diagnostics and Personalized Therapeutics Unit, College of Applied Medical Sciences University of Ha’il
- Mariusz Wasik
- Department of Pathology and Laboratory Medicine, University of Pennsylvania
- Martin Turner
- The Babraham Institute
- Lukas Kenner
- Clinical Institute of Pathology, Medical University of Vienna
- Vahid Asnafi
- Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France
- Elizabeth Macintyre
- Hematology and INSERM1151, Institut Necker-Enfants Malades, Université Sorbonne Paris Cité at Descartes and Assistance Publique-Hôpitaux de Paris, Paris 75743, France
- Suzanne D. Turner
- Department of Pathology, University of Cambridge
- DOI
- https://doi.org/10.1038/ncomms10087
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Anaplastic large cell lymphoma is characterized by an NPM–ALK fusion but the cell of origin for this cancer is unclear. Here, the authors show that, in an NPM–ALK mouse model, the tumours likely arise from early thmyocytes and require an initial burst of TCR signalling for initiation.
