Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis
Jose D. Vargas,
Ani Manichaikul,
Xin-Qun Wang,
Stephen S. Rich,
Jerome I. Rotter,
Wendy S. Post,
Joseph F. Polak,
Matthew J. Budoff,
David A. Bluemke
Affiliations
Jose D. Vargas
MedStar Health Research Institute, Georgetown University Hospital, Washington, District of Columbia, USA; National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA
Ani Manichaikul
Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Xin-Qun Wang
Biostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Stephen S. Rich
Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Jerome I. Rotter
Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA
Wendy S. Post
Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
Joseph F. Polak
Department of Radiology, Tufts University School of Medicine, Boston, MA, USA
Matthew J. Budoff
Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
David A. Bluemke
National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA; Corresponding author: Radiology and Imaging Sciences, NIH Clinical Center, 10 Center Drive, Building 10/1c351, Bethesda, 20892, MD, USA.
Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included. Keywords: Single nucleotide polymorphism (SNP), Common genetic variant, Subclincal atherosclerosis, Coronary artery calcium (CAC), Carotid intima-media thickness (CIMT)
