DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes

Ilke Sen; Xin Zhou; Alexey Chernobrovkin; Nataly Puerta-Cavanzo; Takaharu Kanno; Jérôme Salignon; Andrea Stoehr; Xin-Xuan Lin; Bora Baskaner; Simone Brandenburg; Camilla Björkegren; Roman A. Zubarev; Christian G. Riedel

doi:10.1038/s41467-019-13931-7

Nature Communications (Jan 2020)

DAF-16/FOXO requires Protein Phosphatase 4 to initiate transcription of stress resistance and longevity promoting genes

Ilke Sen,
Xin Zhou,
Alexey Chernobrovkin,
Nataly Puerta-Cavanzo,
Takaharu Kanno,
Jérôme Salignon,
Andrea Stoehr,
Xin-Xuan Lin,
Bora Baskaner,
Simone Brandenburg,
Camilla Björkegren,
Roman A. Zubarev,
Christian G. Riedel

Affiliations

Ilke Sen: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Xin Zhou: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Alexey Chernobrovkin: Department of Medical Biochemistry and Biophysics, Karolinska Institute
Nataly Puerta-Cavanzo: European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen
Takaharu Kanno: Department of Biosciences and Nutrition, Karolinska Institute
Jérôme Salignon: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Andrea Stoehr: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Xin-Xuan Lin: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Bora Baskaner: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute
Simone Brandenburg: European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen
Camilla Björkegren: Department of Biosciences and Nutrition, Karolinska Institute
Roman A. Zubarev: Department of Medical Biochemistry and Biophysics, Karolinska Institute
Christian G. Riedel: Integrated Cardio Metabolic Centre (ICMC), Department of Medicine, Karolinska Institute

DOI: https://doi.org/10.1038/s41467-019-13931-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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The transcription factor DAF-16/FOXO mediates a wide variety of aging-preventive responses by driving the expression of stress resistance and longevity promoting genes. Here the authors show that transcriptional initiation at many DAF-16/FOXO target genes requires the dephosphorylation of SPT-5 by Protein Phosphatase 4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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