Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations
Tatiana V. Kirichenko,
Yulia I. Ragino,
Mikhail I. Voevoda,
Saule J. Urazalina,
Zukhra B. Khasanova,
Varvara A. Orekhova,
Vasily V. Sinyov,
Margarita A. Sazonova,
Alexander N. Orekhov,
Igor A. Sobenin
Affiliations
Tatiana V. Kirichenko
Research Institute of Human Morphology, Moscow, Russia; National Medical Research Center of Cardiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia; Corresponding author. Research Institute of Human Morphology, 3 Tsyurupa Str., 117418, Moscow, Russia.
Yulia I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
Mikhail I. Voevoda
Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
Saule J. Urazalina
JSK Scientific-Research Institute of Cardiology and Internal Diseases, Almaty, Kazakhstan
Zukhra B. Khasanova
National Medical Research Center of Cardiology, Moscow, Russia
Varvara A. Orekhova
National Medical Research Center of Cardiology, Moscow, Russia
Vasily V. Sinyov
National Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia
Margarita A. Sazonova
National Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia
Alexander N. Orekhov
Research Institute of Human Morphology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia
Igor A. Sobenin
Research Institute of Human Morphology, Moscow, Russia; National Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia
The search for variants of mitochondrial genome associated with atherosclerosis, in particular, with carotid intima-media thickness (cIMT), is necessary to understand the role of the damage of mitochondrial genome in the development of atherosclerosis. Such data can be useful to provide novel genetic markers of predisposition to atherosclerosis and molecular targets for further development of technologies aimed to prevent age-related degenerative pathologies. Data presented in this article demonstrate the association of several heteroplasmic variants of mitochondrial DNA (mtDNA) previously described as proatherogenic ones with cIMT in 251 participants (190 participants from Novosibirsk, Russia, and 61 participant from Almaty, Kazakhstan). It was shown that the occurrence of some variants of mitochondrial genome is different in samples derived from Russian and Kazakh populations; the level of mitochondrial heteroplasmy m.13513G > A correlates negatively with mean cIMT in both Russian and Kazakh participants. Keywords: Mitochondrial mutations, Heteroplasmy, Carotid atherosclerosis, Intima-media thickness, Cardiovascular risk factors
