MODIFIED LOW-DENSITY LIPOPROT EINS IN DI ABETES MELLITUS TYPE 2

Abstract

Objective: to compare the level of modified low-density lipoproteins (mLDL) in patients with diabetes mellitus type 2 (DM2) and without DM2; to identify the factors affecting mLDL сontent.Materials and methods. The study involved 64 patients; they were divided into 2 groups. The main group included 32 patients with DM2 (15 men and 17 women, median age – 65 years), the control group 2 included 32 patients without DM2 (15 men and 17 women, median age – 60.5 years). All patients (100 %) had arterial hypertension. Both groups were generally comparable in the main clinical and laboratory characteristics. Mann–Whitney test, Spearman correlation coefficient were used for statistical data processing.Results. In patients with DM2 mLDL level was significantly higher (р <0.001) and correlated with blood glucose concentration (p = 0.021), glycated hemoglobin values (p <0.001) and body-weight index (p = 0.007). In patients without DM2 mLDL level correlated with bodyweight index (p <0.001). No correlation between mLDL level and standard LDL content was found in patients with DM2 and in patients without DM2 (p = 0.714 and p = 0.758 respectively).Conclusion. DM2 is significantly associated with an increased mLDL level that is affected by parameters of carbohydrate metabolism and body-weight index. In persons without hyperlipidemia mLDL level increases in case of hyperglycemia.

Keywords

• diabetes mellitus
• carbohydrate metabolism
• oxidized low-density lipoproteins
• modified low-density lipoproteins
• low-density lipoproteins
• glycated hemoglobin
• glucose
• body-weight index
• arterial hypertension
• dyslipidemia