Characteristics of suboptimal immune response after initiating antiretroviral therapy among people living with HIV with a pre-treatment CD4 T cell count <200 ​cells/mm3 in Thailand

Win Min Han; Sasiwimol Ubolyam; Tanakorn Apornpong; Stephen J. Kerr; Pokrath Hansasuta; Sivaporn Gatechompol; Wirach Maekanantawat; Kiat Ruxrungtham; Praphan Phanuphak; Jintanat Ananworanich; Anchalee Avihingsanon

Journal of Virus Eradication (Sep 2020)

Characteristics of suboptimal immune response after initiating antiretroviral therapy among people living with HIV with a pre-treatment CD4 T cell count <200 cells/mm3 in Thailand

Win Min Han,
Sasiwimol Ubolyam,
Tanakorn Apornpong,
Stephen J. Kerr,
Pokrath Hansasuta,
Sivaporn Gatechompol,
Wirach Maekanantawat,
Kiat Ruxrungtham,
Praphan Phanuphak,
Jintanat Ananworanich,
Anchalee Avihingsanon

Affiliations

Win Min Han: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Sasiwimol Ubolyam: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Tanakorn Apornpong: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Stephen J. Kerr: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Biostatistics Excellence Centre, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia
Pokrath Hansasuta: Division of Virology, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Sivaporn Gatechompol: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Wirach Maekanantawat: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Kiat Ruxrungtham: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Praphan Phanuphak: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Jintanat Ananworanich: SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Global Health, University of Amsterdam, Amsterdam, the Netherlands
Anchalee Avihingsanon: The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Corresponding author. HIV-NAT, Thai Red Cross AIDS Research Centre, 104 Ratchadamri Rd, Pathumwan, Bangkok, 10330, Thailand.

Journal volume & issue: Vol. 6, no. 3
p. 100005

Abstract

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Background: Complete recovery of the CD4 T cell count is uncommon among chronically HIV-infected individuals with very low pre-treatment CD4 count. We studied the prevalence of chronically immune recovery and its associated factors including immune characteristics chronic HIV-infected Thais. Methods: Treatment-naïve participants (n = 375) from the HIV-NAT 006 cohort with a pre-treatment CD4 T cell count after initiating antiretroviral therapy (ART) and having achieved a suppressed viremia (HIV-RNA level 200 cells/mm3 after 3 years of ART which was with a very low pre-ART CD4 T cell count and older age. The long-term clinical outcomes of SIR participants need to be further explored.

Published in Journal of Virus Eradication

ISSN: 2055-6640 (Print); 2055-6659 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Microbiology; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/journal-of-virus-eradication

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