Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Jan 2021)
Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments
- Anja Ophey,
- Steffen Wolfsgruber,
- Sandra Roeske,
- Alexandra Polcher,
- Annika Spottke,
- Lutz Frölich,
- Michael Hüll,
- Frank Jessen,
- Johannes Kornhuber,
- Wolfgang Maier,
- Oliver Peters,
- Alfredo Ramirez,
- Jens Wiltfang,
- Inga Liepelt‐Scarfone,
- Sara Becker,
- Daniela Berg,
- Jörg B. Schulz,
- Kathrin Reetz,
- Jennifer Wojtala,
- Jan Kassubek,
- Alexander Storch,
- Monika Balzer‐Geldsetzer,
- Rüdiger Hilker‐Roggendorf,
- Karsten Witt,
- Brit Mollenhauer,
- Claudia Trenkwalder,
- Hans‐Ullrich Wittchen,
- Oliver Riedel,
- Richard Dodel,
- Michael Wagner,
- Elke Kalbe
Affiliations
- Anja Ophey
- Department of Medical Psychology Neuropsychology & Gender Studies; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany
- Steffen Wolfsgruber
- Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Sandra Roeske
- Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Alexandra Polcher
- Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Annika Spottke
- German Center for Neurodegenerative Diseases (DZNE) Bonn Germany
- Lutz Frölich
- Department of Geriatric Psychiatry Central Institute of Mental Health Medical Faculty Mannheim University of Heidelberg Heidelberg Germany
- Michael Hüll
- Emmendingen Center for Psychiatry and Department of Psychiatry and Psychotherapy University of Freiburg Emmendingen Germany
- Frank Jessen
- Department of Psychiatry and Psychotherapy Faculty of Medicine and University Hospital Cologne University of Cologne Cologne Germany
- Johannes Kornhuber
- Department of Psychiatry and Psychotherapy University Erlangen Erlangen Germany
- Wolfgang Maier
- Department of Psychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Oliver Peters
- Department of Psychiatry Charité – Universitätsmedizin Berlin Berlin Germany
- Alfredo Ramirez
- Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Jens Wiltfang
- Clinic for Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
- Inga Liepelt‐Scarfone
- Hertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany
- Sara Becker
- Hertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany
- Daniela Berg
- Hertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases Tübingen Germany
- Jörg B. Schulz
- Department of Neurology RWTH Aachen University Aachen Germany
- Kathrin Reetz
- Department of Neurology RWTH Aachen University Aachen Germany
- Jennifer Wojtala
- Department of Neurology RWTH Aachen University Aachen Germany
- Jan Kassubek
- Department of Neurology University of Ulm Ulm Germany
- Alexander Storch
- Department of Neurology University of Rostock and German Center for Neurodegenerative Diseases (DZNE) Rostock Germany
- Monika Balzer‐Geldsetzer
- Ethikkommission Ludwig‐Maximilians‐Universität München München Germany
- Rüdiger Hilker‐Roggendorf
- Department of Neurology Klinikum Vest Recklinghausen Germany
- Karsten Witt
- Department of Neurology and Research Centre of Neurosensory Sciences Carl von Ossietzky University Oldenburg Germany
- Brit Mollenhauer
- Paracelsus‐Elena Klinik, Kassel Department of Neurosurgery University Medical Center, Goettingen Kassel Germany
- Claudia Trenkwalder
- Paracelsus‐Elena Klinik, Kassel Department of Neurosurgery University Medical Center, Goettingen Kassel Germany
- Hans‐Ullrich Wittchen
- Department of Psychiatry & Psychotherapy University Hospital Munich Ludwig‐Maximilians‐University Munich Munich Germany
- Oliver Riedel
- Department of Clinical Epidemiology Leibniz Institute for Prevention Research and Epidemiology – BIPS Achterstraße 30 Bremen Germany
- Richard Dodel
- Department of Neurology Philipps University Marburg Baldingerstraße Marburg Germany
- Michael Wagner
- Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany
- Elke Kalbe
- Department of Medical Psychology Neuropsychology & Gender Studies; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany
- DOI
- https://doi.org/10.1002/dad2.12223
- Journal volume & issue
-
Vol. 13,
no. 1
pp. n/a – n/a
Abstract
Abstract Introduction Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare. Methods Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery. Results Patients with AD‐MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD‐MCI showed lower standardized scores in a set‐shifting measure as an executive task. A cross‐validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD‐MCI versus PD‐MCI. Discussion The applied test battery successfully discriminated between AD‐MCI and PD‐MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.
Keywords
- Alzheimer's disease
- Consortium to establish a registry for Alzheimer's disease test battery
- cognitive profiles
- mild cognitive impairment
- neuropsychological assessment
- Parkinson's disease
