Nature Communications (Jun 2019)

Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy

  • Yuan-Li Chen,
  • Jun Tao,
  • Pei-Ji Zhao,
  • Wei Tang,
  • Jian-Ping Xu,
  • Ke-Qin Zhang,
  • Cheng-Gang Zou

DOI
https://doi.org/10.1038/s41467-019-10475-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Decreased temperatures lengthen C. elegans lifespan by mechanisms that are not fully understood. Here the authors show that autophagy activation contributes to lifespan extension at low temperatures and that this involves adiponectin receptor PAQR-2 signaling.