Nature Communications (Oct 2018)
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy
- Feng Liu,
- Jianxia Chen,
- Peng Wang,
- Haohao Li,
- Yilong Zhou,
- Haipeng Liu,
- Zhonghua Liu,
- Ruijuan Zheng,
- Lin Wang,
- Hua Yang,
- Zhenling Cui,
- Fei Wang,
- Xiaochen Huang,
- Jie Wang,
- Wei Sha,
- Heping Xiao,
- Baoxue Ge
Affiliations
- Feng Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jianxia Chen
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Peng Wang
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Haohao Li
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Yilong Zhou
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Haipeng Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zhonghua Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Ruijuan Zheng
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Lin Wang
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Hua Yang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zhenling Cui
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Fei Wang
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Xiaochen Huang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jie Wang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Wei Sha
- Department of TB, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Heping Xiao
- Department of TB, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Baoxue Ge
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06836-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
How Mycobacterium tuberculosis (Mtb) escapes autophagy-mediated clearance is poorly understood. Here, Liu et al. show that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.
