Interdisciplinary Perspectives on Infectious Diseases (Jan 2009)

In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam against Pseudomonas aeruginosa

  • Vladimir Chachanidze,
  • Aixa Curbelo-Irizarry,
  • Deborah Ashcraft,
  • George Pankey

DOI
https://doi.org/10.1155/2009/984934
Journal volume & issue
Vol. 2009

Abstract

Read online

In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested.