Coumarins and P450s, Studies Reported to-Date

Maryam Foroozesh; Jayalakshmi Sridhar; Navneet Goyal; Jiawang Liu

doi:10.3390/molecules24081620

Molecules (Apr 2019)

Coumarins and P450s, Studies Reported to-Date

Maryam Foroozesh,
Jayalakshmi Sridhar,
Navneet Goyal,
Jiawang Liu

Affiliations

Maryam Foroozesh: Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA
Jayalakshmi Sridhar: Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA
Navneet Goyal: Department of Chemistry, Xavier University of Louisiana, 1 Drexel Dr., New Orleans, LA 70125, USA
Jiawang Liu: Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison Ave., Memphis, TN 38163, USA

DOI: https://doi.org/10.3390/molecules24081620
Journal volume & issue: Vol. 24, no. 8
p. 1620

Abstract

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Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosynthesis of endogenous compounds and the bioactivation of xenobiotics. Coumarins, phytochemicals abundant in food and commonly used in fragrances and cosmetics, have been shown to interact with P450 enzymes as substrates and/or inhibitors. In this review, these interactions and their significance in pharmacology and toxicology are discussed in detail.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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