Nature Communications (Jan 2023)
Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial
- Bryan P. Brown,
- Colin Feng,
- Ramla F. Tanko,
- Shameem Z. Jaumdally,
- Rubina Bunjun,
- Smritee Dabee,
- Anna-Ursula Happel,
- Melanie Gasper,
- Donald D. Nyangahu,
- Maricianah Onono,
- Gonasagrie Nair,
- Thesla Palanee-Phillips,
- Caitlin W. Scoville,
- Kate Heller,
- Jared M. Baeten,
- Steven E. Bosinger,
- Adam Burgener,
- Jo-Ann S. Passmore,
- Renee Heffron,
- Heather B. Jaspan
Affiliations
- Bryan P. Brown
- Seattle Children’s Research Institute
- Colin Feng
- Seattle Children’s Research Institute
- Ramla F. Tanko
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Shameem Z. Jaumdally
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Rubina Bunjun
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Smritee Dabee
- Seattle Children’s Research Institute
- Anna-Ursula Happel
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Melanie Gasper
- Seattle Children’s Research Institute
- Donald D. Nyangahu
- Seattle Children’s Research Institute
- Maricianah Onono
- Kenya Medical Research Institute
- Gonasagrie Nair
- Desmond Tutu HIV Centre
- Thesla Palanee-Phillips
- Wits Reproductive Health and HIV Institute
- Caitlin W. Scoville
- University of Washington
- Kate Heller
- University of Washington
- Jared M. Baeten
- University of Washington
- Steven E. Bosinger
- Yerkes National Primate Research Center
- Adam Burgener
- Center for Global Health and Diseases, Case Western Reserve University
- Jo-Ann S. Passmore
- Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
- Renee Heffron
- University of Washington
- Heather B. Jaspan
- Seattle Children’s Research Institute
- DOI
- https://doi.org/10.1038/s41467-023-36002-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Here, in a randomized trial, the authors comparatively evaluate the effect of a copper intrauterine device versus other contraceptive options on the vaginal environment after one and six consecutive months of use, finding to exert changes on the vaginal microbiota that may potentially lead to detrimental sex and reproductive health.
