Evaluation of Platelet-to-Lymphocyte Ratio in Predicting Early and Long Term Outcomes Following Acute Coronary Syndrome

Abstract

BACKGROUND AND OBJECTIVE: The platelet-to-lymphocyte ratio (PLR) might be an important and critical measure in evaluating and anticipating undesirable outcomes in patients with acute coronary syndrome (ACS). What was discussed in this study was systemic evaluation of the role of PLR in predicting adverse outcomes of ACS (including mortality and MACE) both in the short term and in the long term. METHODS: In this systematic review, studies related to platelet counts, lymphocytes, acute coronary artery syndrome were searches in Medline, Web of knowledge, Google scholar, Scopus, and Cochrane databases. Finally, 15 related studies were reviewed, including 7 prospective studies and 8 retrospective studies. FINDINGS: In a review of 15 articles, a total of 8304 patients in the group with low PLR and 5822 patients in the group with high PLR were considered. The increase in PLR can increase the risk of short-term and long-term mortality by 0.3 and 1.8 times, respectively. CONCLUSION: Based on the results of this study, the increase in PLR can effectively predict early and long term adverse events in patients with ACS.

Keywords

• blood platelets
• lymphocytes
• acute coronary syndrome.