The complex link between the gut microbiome and obesity-associated metabolic disorders: Mechanisms and therapeutic opportunities
Kexin Zhang,
Qi Zhang,
Hongyan Qiu,
Yanhui Ma,
Ningning Hou,
Jingwen Zhang,
Chengxia Kan,
Fang Han,
Xiaodong Sun,
Junfeng Shi
Affiliations
Kexin Zhang
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Qi Zhang
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China
Hongyan Qiu
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Yanhui Ma
Department of Pathology, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Ningning Hou
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Jingwen Zhang
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Chengxia Kan
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Fang Han
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China; Department of Pathology, Affiliated Hospital of Shandong Second Medical University, Weifang, China
Xiaodong Sun
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China; Corresponding author. Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, 2428 Yuhe Road, Weifang, 261031, China.
Junfeng Shi
Department of Endocrinology and Metabolism, Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Shandong Second Medical University, Weifang, China; Clinical Research Center, Affiliated Hospital of Shandong Second Medical University, Weifang, China; Corresponding author. Department of Endocrinology and Metabolism, Department of Pathology, Affiliated Hospital of Shandong Second Medical University, 2428 Yuhe Road, Weifang, 261031, China.
Microbial interactions are widespread and important processes that support the link between disease and microbial ecology. The gut microbiota is a major source of microbial stimuli that can have detrimental or beneficial effects on human health. It is also an endocrine organ that maintains energy homeostasis and host immunity. Obesity is a highly and increasingly prevalent metabolic disease and the leading cause of preventable death worldwide. An imbalance in the gut microbiome is associated with several diseases including obesity-related metabolic disorders. This review summarizes the complex association between the gut microbiome and obesity-associated metabolic diseases and validates the role and mechanisms of ecological dysregulation in the gut in obesity-associated metabolic disorders. Therapies that could potentially alleviate obesity-associated metabolic diseases by modulating the gut microbiota are discussed.
