mBio
(Jun 2021)
Loss of the Bacterial Flagellar Motor Switch Complex upon Cell Lysis
Mohammed Kaplan,
Elitza I. Tocheva,
Ariane Briegel,
Megan J. Dobro,
Yi-Wei Chang,
Poorna Subramanian,
Alasdair W. McDowall,
Morgan Beeby,
Grant J. Jensen
Affiliations
Mohammed Kaplan
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Elitza I. Tocheva
ORCiD Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Ariane Briegel
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Megan J. Dobro
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Yi-Wei Chang
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Poorna Subramanian
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Alasdair W. McDowall
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Morgan Beeby
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
Grant J. Jensen
ORCiD Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA
DOI
https://doi.org/10.1128/mBio.00298-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
The bacterial flagellar motor is a complex macromolecular machine whose function and self-assembly present a fascinating puzzle for structural biologists. Here, we report that in diverse bacterial species, cell lysis leads to loss of the cytoplasmic switch complex and associated ATPase before other components of the motor.
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