Short–term effect of chlorpromazine and diazepam on blood plasma acetylcholinesterase activity in chicks

Abstract

The response of blood plasma acetylcholinestrase to acute administration of chlorpromazine and diazepam was examined in chick. Chlorpromazine in a dose–dependent manner at 25, 50, and 75 mg/Kg, subcutaneously inhibited the activity of Ache in the blood. Chlorpromazine (50, 75 mg /kg) significantly decreased the enzyme activity in the plasma by 14.7 % and 17.6 %, respectively for a period of 60 min, as well as, 14.5 % and 13.1 % for a period of 60 and 120 min, respectively in groups received chlorpromazine 50 mg/kg. Diazepam at 10, 20 and 30 mg/kg subcutaneously did not significantly affect the enzyme activity in comparison with the control group. The result suggests that chlorpromazine changes Ache activity in the blood and possibly in other tissues.