The Influence of Ozonated Olive Oil-Loaded and Copper-Doped Nanohydroxyapatites on Planktonic Forms of Microorganisms
Wojciech Zakrzewski,
Maciej Dobrzynski,
Joanna Nowicka,
Magdalena Pajaczkowska,
Maria Szymonowicz,
Sara Targonska,
Paulina Sobierajska,
Katarzyna Wiglusz,
Wojciech Dobrzynski,
Adam Lubojanski,
Sebastian Fedorowicz,
Zbigniew Rybak,
Rafal J. Wiglusz
Affiliations
Wojciech Zakrzewski
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland
Maciej Dobrzynski
Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
Joanna Nowicka
Department of Microbiology, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland
Magdalena Pajaczkowska
Department of Microbiology, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland
Maria Szymonowicz
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland
Sara Targonska
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland
Paulina Sobierajska
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland
Katarzyna Wiglusz
Department of Analytical Chemistry, Wroclaw Medical University, Borowska 211 A, 50-566 Wroclaw, Poland
Wojciech Dobrzynski
Student Scientific Circle at the Department of Dental Materials, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Akademicki Sq. 17, 41-902 Bytom, Poland
Adam Lubojanski
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland
Sebastian Fedorowicz
Department of Microbiology, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland
Zbigniew Rybak
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland
Rafal J. Wiglusz
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland
The research has been carried out with a focus on the assessment of the antimicrobial efficacy of pure nanohydroxyapatite, Cu2+-doped nanohydroxyapatite, ozonated olive oil-loaded nanohydroxyapatite, and Cu2+-doped nanohydroxyapatite, respectively. Their potential antimicrobial activity was investigated against Streptococcus mutans, Lactobacillus rhamnosus, and Candida albicans. Among all tested materials, the highest efficacy was observed in terms of ozonated olive oil. The studies were performed using an Ultraviolet–Visible spectrophotometry (UV-Vis), electron microscopy, and statistical methods, by determining the value of Colony-Forming Units (CFU/mL) and Minimal Inhibitory Concentration (MIC).
