A case of refractory T-cell lymphoblastic lymphoma coexisting with ZMYM2-fibroblastic growth factor receptor-1 fusion-related myeloproliferative disease and review of literatures

Abstract

T-cell LBL (T-LBL) is a rare lymphoma subtype in adults, and it usually has a dismal prognosis compared to other subtypes of non-Hodgkin lymphoma. Here, we present a unique case of T-LBL with myeloproliferative disease. A distinct fusion gene of ZMYM2-FGFR1 translocation was detected through next-generation sequencing, and this might be correlated with the translocation of chromosomes 8 and 13 (t[8;13]). Her disease condition seemed to be refractory to multiple lines of chemotherapy. Her lymphoma finally achieved a complete remission after a matched related allogeneic hematopoietic stem cell transplantation.

Keywords

• t-cell lymphoblastic lymphoma
• myeloproliferative disease
• zmym2-fibroblastic growth factor receptor-1 fusion gene
• allogeneic hematopoietic stem cell transplantation