Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G > A mutation in PTGIS gene

Yong-Jian Zhu; Si-Jin Zhang; Xiao-Han Wu; Tian-Yu Lian; Yang-Zhige He; Ze-Jian Zhang; Dan Lu; Kai Sun; Hui-Fang Wang; Zhi-Cheng Jing

Stem Cell Research (Dec 2020)

Generation of an induced pluripotent stem cell line (PUMCHi006-A) derived from a patient with pulmonary arterial hypertension carrying heterozygous c.1339 G > A mutation in PTGIS gene

Yong-Jian Zhu,
Si-Jin Zhang,
Xiao-Han Wu,
Tian-Yu Lian,
Yang-Zhige He,
Ze-Jian Zhang,
Dan Lu,
Kai Sun,
Hui-Fang Wang,
Zhi-Cheng Jing

Affiliations

Yong-Jian Zhu: State Key Laboratory of Complex, Severe and Rare Disease and Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Si-Jin Zhang: Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
Xiao-Han Wu: State Key Laboratory of Complex, Severe and Rare Disease and Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Tian-Yu Lian: State Key Laboratory of Complex, Severe and Rare Disease and Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Yang-Zhige He: State Key Laboratory of Complex, Severe and Rare Disease and Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Ze-Jian Zhang: State Key Laboratory of Complex, Severe and Rare Disease and Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Dan Lu: State Key Laboratory of Complex, Severe and Rare Disease and Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Kai Sun: State Key Laboratory of Complex, Severe and Rare Disease and Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Hui-Fang Wang: Department of Medical Laboratory, Weifang Medical University, Weifang, Shandong, China
Zhi-Cheng Jing: State Key Laboratory of Complex, Severe and Rare Disease and Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding author at: Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing 100730, China.

Journal volume & issue: Vol. 49
p. 102088

Abstract

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Our previous study found that mutations in the PTGIS gene contributed high susceptibility to pulmonary arterial hypertension (PAH). We have generated disease-specific induced pluripotent stem cell (iPSC) lines from a PAH patient carrying the heterozygous c.1339 G > A mutation in PTGIS gene. The generated iPSC lines can be differentiated into endothelial cells to investigate the pathogenesis of PAH associated with PTGIS gene, which could provide valuable resources for personalized medicine.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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