Liquid-Liquid Phase Separation at the Surface of Dissolving Drug Salt Particles: Prediction

Abstract

This study aimed to show how the amount of liquid in a liquid mixture separates, and how it relates to the science of heat and energy.We did experiments to study the liquid phase separation, as well as the ability of drug-like molecules to dissolve in crystal form. The CLME equation was derived based on how heat and energy affect things, like how much substance can dissolve in a liquid, how strong the concentration is, and the temperature at which it melts [denoted as Tm]. The equation is [𝑙𝑜𝑔10 =𝑙𝑜𝑔10 −0.0095 [𝑇𝑚−310] for 310 K. The scientists tested 31 drugs by changing the pH or solvent of the substance and using lasers to see if there were any changes in how they looked. To ensure the material didn't form crystals within 10 seconds, I used a special microscope that utilizes polarized light to conduct some tests.The measured and calculated values showed a strong similarity [with a small error of 0. 40 log units]. The average error was 0. 32 log units.

Keywords

• liquid–liquid phase separation
• intrinsic solubility
• melting point
• drug-like