In vivo engraftment into the cornea endothelium using extracellular matrix shrink-wrapped cells

Rachelle N. Palchesko; Yiqin Du; Moira L. Geary; Santiago Carrasquilla; Daniel J. Shiwarski; Irona Khandaker; James L. Funderburgh; Adam W. Feinberg

doi:10.1038/s43246-022-00247-1

Communications Materials (Apr 2022)

In vivo engraftment into the cornea endothelium using extracellular matrix shrink-wrapped cells

Rachelle N. Palchesko,
Yiqin Du,
Moira L. Geary,
Santiago Carrasquilla,
Daniel J. Shiwarski,
Irona Khandaker,
James L. Funderburgh,
Adam W. Feinberg

Affiliations

Rachelle N. Palchesko: Department of Biomedical Engineering, Carnegie Mellon University
Yiqin Du: Department of Ophthalmology, University of Pittsburgh
Moira L. Geary: Department of Ophthalmology, University of Pittsburgh
Santiago Carrasquilla: Department of Biomedical Engineering, Carnegie Mellon University
Daniel J. Shiwarski: Department of Biomedical Engineering, Carnegie Mellon University
Irona Khandaker: Department of Ophthalmology, University of Pittsburgh
James L. Funderburgh: Department of Ophthalmology, University of Pittsburgh
Adam W. Feinberg: Department of Biomedical Engineering, Carnegie Mellon University

DOI: https://doi.org/10.1038/s43246-022-00247-1
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 12

Abstract

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Tissue regeneration by injecting cells into the damaged area is a common clinical treatment, but is not always affective. Here, a shrink-wrap-like process is reported for corneal endothelial cells, allowing them to be engrafted into the corneal endothelium of a rabbit animal model.

Published in Communications Materials

ISSN: 2662-4443 (Online)
Publisher: Nature Portfolio
Country of publisher: United States
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.nature.com/commsmat/

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