JACC: Case Reports (May 2024)

Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm

  • Abbas Hoteit, MD,
  • Faye Victoria C. Casimero, MD,
  • James R. Stone, MD, PhD,
  • Duke Cameron, MD,
  • Eric M. Isselbacher, MD, MSc,
  • Reza Seyedsadjadi, MD,
  • Hanna K. Gaggin, MD, MPH

Journal volume & issue
Vol. 29, no. 9
p. 102311

Abstract

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Amyloid deposition in aortic tissue is associated with increased stiffness. We report a patient with ascending aortic aneurysm and chronic abdominal aortic dissection who had significant wild-type transthyretin amyloid deposition on surgical pathology. The patient did not have cardiac involvement on further workup.

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