Nature Communications (Jul 2019)
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
- Vahid Kheirollahi,
- Roxana M. Wasnick,
- Valentina Biasin,
- Ana Ivonne Vazquez-Armendariz,
- Xuran Chu,
- Alena Moiseenko,
- Astrid Weiss,
- Jochen Wilhelm,
- Jin-San Zhang,
- Grazyna Kwapiszewska,
- Susanne Herold,
- Ralph T. Schermuly,
- Bernard Mari,
- Xiaokun Li,
- Werner Seeger,
- Andreas Günther,
- Saverio Bellusci,
- Elie El Agha
Affiliations
- Vahid Kheirollahi
- Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University
- Roxana M. Wasnick
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Valentina Biasin
- Ludwig Boltzmann Institute for Lung Vascular Research, Otto Loewi Research Center, Medical University Graz
- Ana Ivonne Vazquez-Armendariz
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Xuran Chu
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Alena Moiseenko
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Astrid Weiss
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Jochen Wilhelm
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Jin-San Zhang
- International Collaborative Center on Growth Factor Research and School of Pharmaceutical Sciences, Wenzhou Medical University
- Grazyna Kwapiszewska
- Ludwig Boltzmann Institute for Lung Vascular Research, Otto Loewi Research Center, Medical University Graz
- Susanne Herold
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Ralph T. Schermuly
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Bernard Mari
- Institut de Pharmacologie Moleculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS), UMR 7275
- Xiaokun Li
- International Collaborative Center on Growth Factor Research and School of Pharmaceutical Sciences, Wenzhou Medical University
- Werner Seeger
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Andreas Günther
- Cardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen
- Saverio Bellusci
- Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University
- Elie El Agha
- Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-019-10839-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.
