BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism

Jiahui Du; Yili Liu; Xiaolin Wu; Jinrui Sun; Junfeng Shi; Hongming Zhang; Ao Zheng; Mingliang Zhou; Xinquan Jiang

doi:10.1038/s41467-023-37116-5

Nature Communications (Mar 2023)

BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism

Jiahui Du,
Yili Liu,
Xiaolin Wu,
Jinrui Sun,
Junfeng Shi,
Hongming Zhang,
Ao Zheng,
Mingliang Zhou,
Xinquan Jiang

Affiliations

Jiahui Du: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Yili Liu: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Xiaolin Wu: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Jinrui Sun: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Junfeng Shi: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Hongming Zhang: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Ao Zheng: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Mingliang Zhou: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Xinquan Jiang: Department of Prosthodontics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-023-37116-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 20

Abstract

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Osteoclast differentiation is critical for bone homeostasis. The authors show the negative feedback regulation of BRD9-mediated chromatin remodeling on osteoclastogenesis via interferon beta signaling and its therapeutic potential for bone diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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