Synthesis, Characterization and Preliminary Antibacterial Evaluation against <i>Staphylococcus aureus</i> of a New 2,4,5-Tri(hetero)arylimidazole Derivative Based on Azaindole Heterocycle

Abstract

Imidazole derivatives are known for their varied biological applications, such as antibacterial, antifungal, antioxidant, antiviral, antiparasitic and anticancer compounds, among others. Therefore, numerous imidazole derivatives have been synthesized and developed in recent years as potential drugs in the treatment of several diseases. In this communication, we report the synthesis of a new imidazole derivative, substituted at positions 2, 4 and 5 with heterocyclic groups, using a simple synthetic methodology and an easy purification procedure. The new compound was characterized by the usual spectroscopic techniques (NMR, UV-Vis absorption and emission). The evaluation of the novel imidazole derivative as a potential antibiotic drug was carried out against the Gram-positive bacterium Staphylococcus aureus, using the disk test diffusion method. The results showed a dose–response effect against the bacterium under study, revealing that the rational design of this imidazole derivative is quite promising to improve the antibacterial activity of imidazole derivatives.

Keywords

• imidazole
• synthesis
• antibacterial activity
• <i>Staphylococcus aureus</i>