N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

Zihan Li; Yanxi Peng; Jiexin Li; Zhuojia Chen; Feng Chen; Jian Tu; Shuibin Lin; Hongsheng Wang

doi:10.1038/s41467-020-16306-5

Nature Communications (May 2020)

N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4

Zihan Li,
Yanxi Peng,
Jiexin Li,
Zhuojia Chen,
Feng Chen,
Jian Tu,
Shuibin Lin,
Hongsheng Wang

Affiliations

Zihan Li: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University
Yanxi Peng: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University
Jiexin Li: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University
Zhuojia Chen: Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine
Feng Chen: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University
Jian Tu: Institute of Pharmacy & Pharmacology, University of South China
Shuibin Lin: Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University
Hongsheng Wang: Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University

DOI: https://doi.org/10.1038/s41467-020-16306-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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