Nature Communications (Nov 2017)
MafB is a critical regulator of complement component C1q
- Mai Thi Nhu Tran,
- Michito Hamada,
- Hyojung Jeon,
- Risako Shiraishi,
- Keigo Asano,
- Motochika Hattori,
- Megumi Nakamura,
- Yuki Imamura,
- Yuki Tsunakawa,
- Risa Fujii,
- Toshiaki Usui,
- Kaushalya Kulathunga,
- Christina-Sylvia Andrea,
- Ryusuke Koshida,
- Risa Kamei,
- Yurina Matsunaga,
- Makoto Kobayashi,
- Hisashi Oishi,
- Takashi Kudo,
- Satoru Takahashi
Affiliations
- Mai Thi Nhu Tran
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Michito Hamada
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Hyojung Jeon
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Risako Shiraishi
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Keigo Asano
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Motochika Hattori
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Megumi Nakamura
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Yuki Imamura
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Yuki Tsunakawa
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Risa Fujii
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Toshiaki Usui
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Kaushalya Kulathunga
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Christina-Sylvia Andrea
- Department of Molecular and Developmental Biology, Faculty of Medicine, University of Tsukuba
- Ryusuke Koshida
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Risa Kamei
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Yurina Matsunaga
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Makoto Kobayashi
- Department of Molecular and Developmental Biology, Faculty of Medicine, University of Tsukuba
- Hisashi Oishi
- Department of Comparative and Experimental Medicine, Nagoya City University Graduate 24 School of Medical Sciences
- Takashi Kudo
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- Satoru Takahashi
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
- DOI
- https://doi.org/10.1038/s41467-017-01711-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.
