Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China

Cheng Zhang; Cheng Zhang; Kangkang Guo; Kangkang Guo; Huan Cui; Huan Cui; Ligong Chen; Chunmao Zhang; Xuejing Wang; Jiaming Li; Yingying Fu; Zhongyi Wang; Zhendong Guo; Juxiang Liu; Shishan Dong

doi:10.3389/fcimb.2021.688007

Frontiers in Cellular and Infection Microbiology (Jun 2021)

Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China

Cheng Zhang,
Cheng Zhang,
Kangkang Guo,
Kangkang Guo,
Huan Cui,
Huan Cui,
Ligong Chen,
Chunmao Zhang,
Xuejing Wang,
Jiaming Li,
Yingying Fu,
Zhongyi Wang,
Zhendong Guo,
Juxiang Liu,
Shishan Dong

Affiliations

Cheng Zhang: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China
Cheng Zhang: Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China
Kangkang Guo: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China
Kangkang Guo: Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China
Huan Cui: Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China
Huan Cui: College of Animal Medicine, Jilin University, Changcchun, China
Ligong Chen: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China
Chunmao Zhang: Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China
Xuejing Wang: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China
Jiaming Li: Beijing Institute of Biotechnology, Beijing, China
Yingying Fu: Beijing Institute of Biotechnology, Beijing, China
Zhongyi Wang: Beijing Institute of Biotechnology, Beijing, China
Zhendong Guo: Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun, China
Juxiang Liu: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China
Shishan Dong: College of Veterinary Medicine, Hebei Agricultural University, Baoding, China

DOI: https://doi.org/10.3389/fcimb.2021.688007
Journal volume & issue: Vol. 11

Abstract

Read online

Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

About the journal

Abstract

Keywords