Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

Kouichi Yamamoto; Naoko Kureyama; Keiko Asano; Toshiji Ikeda; Atsushi Yamatodani

Journal of Pharmacological Sciences (Jan 2010)

Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

Kouichi Yamamoto,
Naoko Kureyama,
Keiko Asano,
Toshiji Ikeda,
Atsushi Yamatodani

Affiliations

Kouichi Yamamoto: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan; Corresponding author. [email protected]
Naoko Kureyama: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Keiko Asano: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Toshiji Ikeda: Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan
Atsushi Yamatodani: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan

Journal volume & issue: Vol. 112, no. 1
pp. 118 – 120

Abstract

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We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK1R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK1R. Keywords:: radiation-induced hair loss, substance P, neurokinin-1 receptor

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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