Pleuroparenchymal fibroelastosis secondary to autologous peripheral blood stem cell transplantation: A case report

Abstract

Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonitis. Although most cases of PPFE are idiopathic, some cases of PPFE occur secondary to stem cell transplantation. We report a 41-year-old woman developed pneumonia after autologous peripheral blood system cell transplantation (PBSCT). Eleven years after PBSCT, she presented with dyspnea. A computed tomographic scan showed pleuroparenchymal thickening and predominantly in the upper lobes. She was diagnosed with PPFE secondary to PBSCT. She was started nintedanib and administered oxygen therapy. Most cases of PPFE secondary to stem cell transplantation have been reported. However, we experienced the case of PPFE post-autologous PBSCT.

Keywords

• Pleuroparenchymal fibroelastosis (PPFE)
• Idiopathic interstitial pneumonia (IIP)
• Hematopoietic stem cell transplantation (HSCT)
• Peripheral blood stem cell transplantation (PBSCT)
• Graft-versus-host disease (GVHD)